Publications

2020

(Co)-corresponding author
Hoogendoorn, S.    , van Puijvelde, G.H.M., van der Marel, G.A., van Koppen, C.J., Timmers, C.M., Overkleeft, H.S. (2020) Fluorescent Small-Molecule Agonists as Follicle-Stimulating Hormone Receptor Imaging Tools, RSC Chemical Biology, Advance Article. 
Hoogendoorn, S.   (2020) Small Molecules Targeting the Hedgehog Pathway: From Phenotype to Mechanistic Understanding, CHIMIA (accepted)
Invited contribution for the special issue 'New Professors'
 
Hoogendoorn, S.    , Aye, Y. (2020) Empowering Global Chemical Biology at the Dawn of the New Decade, ACS Chemical Biology, 15:1287-1291
conference report

2018

Breslow, D.K.*, Hoogendoorn, S.*, Kopp, A.R., Morgens, D.W., Vu, B.K., Kennedy, M.C., Han, K., Li, A., Hess, G.T., Bassik, M.C., Chen, J.K., Nachury, M.V. (2018). A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Nature Genetics, 50:460-471. * Co-first author. BioRxiv:  https://doi.org/10.1101/156059

2017

Kallemeijn, W.W., Scheij, S., Hoogendoorn, S., Witte, M.D., Herrera Moro Chao, D., van Roomen, C.P.A.A., Ottenhoff, R., Overkleeft, H.S., Boot, R.G., Aerts, J.M.F.G. (2017). Investigations on therapeutic glucocerebrosidases through paired detection with fluorescent activity-based probes. PLoS ONE 12(2): e0170268.

2016

de Bruin, G., Mock, E.D., Hoogendoorn, S., van den Nieuwendijk, A.M.C.H., Mazurek, J., van der Marel, G.A., Florea, B.I., Overkleeft, H.S. (2016). Enantioselective synthesis of adamantylalanine and carboranylalanine and their incorporation into the proteasome inhibitor bortezomib. Chemical Communications 52:4064-4067.

 

See, S.K., Hoogendoorn, S., Chung, A.H., Ye, F., Steinman, J.B., Sakata-Kato, T., Miller, R.M., Cupido, T., Zalyte, R., Carter, A.P., Nachury, M.V., Kapoor, T.M., Chen, J.K. (2016). Cytoplasmic Dynein Antagonists with Improved Potency and Isoform Selectivity. ACS Chemical Biology, 11:53–60.

2015

van den Berg, R. J. B. H. N., van Rijssel, E. R., Ferraz, M. J., Houben, J., Strijland, A., Donker-Koopman, W. E., Wennekes, T., Bonger, K. M., Ghisaidoobe, A. B. T., Hoogendoorn, S., van der Marel, G. A., Codée, J. D. C., Overkleeft, H. S., Aerts, J. M. F. G. (2015). Synthesis and Evaluation of Hybrid Structures Composed of Two Glucosylceramide Synthase Inhibitors. ChemMedChem, 12:2042-2062

 

Hoogendoorn, S.*, Mock, E. D.*, Strijland, A., Donker-Koopman, W. E., van den Elst, H., van den Berg, R. J. B. H. N., Aerts, J. M. F. G., van der Marel, G. A., Overkleeft, H. S. (2015). Ortho-Carborane-Modified N-Substituted Deoxynojirimycins. European Journal of Organic Chemistry 20:4437-4446. *Co-first author

 

Wong, C.-S.*, Hoogendoorn, S.*, van der Marel, G.A., Overkleeft, H.S., Codée, J.C. (2015). Targeted Delivery of Fluorescent High-Mannose-Type Oligosaccharide Cathepsin Inhibitor Conjugates. ChemPlusChem 80:928-937. *Co-first author

 

Liu, N., Hoogendoorn, S., van de Kar, B., Kaptein, A., Barf, T., Driessen, C., Filippov, D.V., van der Marel, G. A., van der Stelt, M., Overkleeft, H.S. (2015). Direct and two-step bioorthogonal probes for Bruton’s tyrosine kinase based on ibrutinib: a comparative study. Organic & Biomolecular Chemistry 13:5147-5157.

2014

Hoogendoorn, S., van Puijvelde, G.H.M., Kuiper, J., van der Marel, G.A., Overkleeft, H.S. (2014). A Multivalent Ligand for the Mannose-6-Phosphate Receptor for Endolysosomal Targeting of an Activity-Based Probe. Angewandte Chemie Int. Ed. 53: 10975-10978.

 

Li, K.-Y., Jiang, J., Witte, M.D., Kallemeijn, W.W., van den Elst, H., Wong, C.-S., Chander, S.D., Hoogendoorn, S., Beenakker, T.J.M., Codée, J.D.C., Aerts, J.M.F.G., van der Marel, G.A., Overkleeft, H.S. (2014). Synthesis of Cyclophellitol, Cyclophellitol Aziridine, and Their Tagged Derivatives. European Journal of Organic Chemistry, 27: 6030-6043.

2013

Baggelaar, M.P., Janssen, F.J., van Esbroeck, A.C.M., den Dulk, H., Allara, M., Hoogendoorn, S., McGuire, R., Florea, B., Meeuwenoord, N., van den Elst, H., Visser, L., van der Marel, G.A., Brouwer, J., Doherty, P., Di Marzo, V., Overkleeft, H.S., van der Stelt, M. (2013). Identification of Novel DAG-lipase-α Inhibitors with Unprecedented Selectivity in Brain Using Comparative ABPP and In Silico Design. Angewandte Chemie Int. Ed. 52: 12081-12085.

2012

Van der Linden, W.A., Li, N., Hoogendoorn, S., Ruben, M., Verdoes, M., Guo, J., Boons, G.-J., van der Marel, G.A., Florea, B.I., Overkleeft, H.S. Two-step bioorthogonal activity-based proteasome profiling using copper-free click reagents:  A comparative study.  Bioorganic & Medicinal Chemistry (2012) 20:662-666.

2011

Willems, L.I., van der Linden, W.A., Li, N., Li, K.-Y., Liu, N., Hoogendoorn, S., van der Marel, G.A., Florea, B.I., Overkleeft, H.S. (2011). Bioorthogonal chemistry: Applications in activity-based protein profiling. Accounts of Chemical Research 44: 718-729. Review.

 

Hoogendoorn, S., Willems, L., Florea, B., Overkleeft, H. Hypersensitive response to over-reactive cysteines. (2011). Angewandte Chemie Int. Ed. 50: 5434-5436. Highlight.

 

Hoogendoorn, S., Blom A.E.M., Willems, L.I., van der Marel, G.A., Overkleeft, H.S. (2011). Synthesis of pH–activatable red fluorescent BODIPY dyes with distinct functionalities. Organic Letters, 13: 5656-5659.

 

Hoogendoorn, S., Habets, K.L., Passemard, S., Kuiper, J., van der Marel, G.A., Florea, B.I., Overkleeft, H.S. (2011). Targeted pH-dependent fluorescent activity-based cathepsin probes. Chemical Communications 47: 9363-9365.

 

Bonger, K.M.*, Hoogendoorn, S.*, van Koppen, C.J., Timmers, C.M., van der Marel, G.A., Overkleeft, H.S. (2011). Development of selective LH receptor agonists by heterodimerization with a FSH receptor antagonist. ACS Medicinal Chemistry Letters 2: 85-89. *Co-first author

2010

Van Delft, P., Meeuwenoord, N.J., Hoogendoorn, S., Dinkelaar, J., Overkleeft, H.S., van der Marel, G.A., Filippov, D.V. (2010). Synthesis of oligoribonucleic acid conjugates using a cyclooctyne phosphoramidite. Organic Letters 12:5486-5489.

2009

Bonger, K.M.*, Hoogendoorn, S.*, van Koppen, C.J., Timmers, C.M., Overkleeft, H.S., van der Marel, G.A. (2009). Synthesis and pharmacological evaluation of dimeric follicle-stimulating hormone receptor antagonists. ChemMedChem 4:2098-2102. *Co-first author

 

Gomes, I., Grushko, J.S., Golebiewska, U., Hoogendoorn, S., Gupta, A., Heimann, A.S., Ferro, E.S., Scarlata, S., Fricker, L.D., Devi, L.A. (2009). Novel endogenous peptide agonists of cannabinoid receptors. FASEB J. 23:3020-3029.

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© 2020 created by Sascha Hoogendoorn